TY - BOOK AU - Mushegian,Arcady R. TI - Foundations of comparative genomics SN - 9780120887941 (hard cover : alk. paper) AV - QH447 .M88 2007 PY - 2007/// CY - Amsterdam, Boston PB - Academic Press KW - Genomics KW - Gene mapping KW - Physiology, Comparative KW - methods KW - Genetic Techniques KW - Sequence Analysis N1 - Includes bibliographical references (p. 238-257) and index; The beginning of computational genomics -- Finding sequence similarities -- Homology: can we get it right? -- Getting ready for the era of comparative genomics: the importance of viruses -- The first fact of comparative genomics: protein sequences are remarkably resilient in evolution -- The second fact of comparative genomics: functional convergence at the molecular level -- Prediction of function and reconstruction of metabolism from genomic data: homology-based approaches -- Prediction of function and reconstruction of metabolism: post-homology approaches -- Structural genomics: what does it tell us about life? -- How many protein families are there? -- Phylogenetic inference and the era of complete genomes -- Two stories about evolution -- Minimal and ancestral genomes -- Comparative genomics and systems biology UR - http://www.loc.gov/catdir/toc/ecip079/2007003418.html UR - http://www.loc.gov/catdir/enhancements/fy0707/2007003418-d.html ER -