Gene discovery for disease models

Additional authors: Gu, Weikuan.
Published by : Wiley, (Hoboken, N.J. :) Physical details: xiii, 537 p. : ill. (some col.) ; 25 cm. ISBN:9780470499467 (cloth); 047049946X (cloth). Year: 2011
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Item type Current library Call number Status Date due Barcode
Books Books Cental Instituite of Fisheries Education
616.042/GU (Browse shelf(Opens below)) Available 21812

Includes bibliographical references and index.

Introduction : gene discovery-from positional cloning to genomic cloning -- High throughput gene expression analysis and the identification of expression QTLs -- DNA methylation in the pathogenesis of autoimmunity -- Ccell-based analysis with microfluidic chip -- Missing dimension : protein turnover rate measurement in gene discovery -- Bioinformatics tools for the prediction of gene function -- Determination of genomic locations of targeted genetic loci -- Mutation discovery using high throughput mutation screening technology -- Candidate screening through gene expression profile -- Candidate screening through high-density SNP array -- Gene discovery through direct genome sequencing -- Candidate screening through bioinformatics tools -- Using an integrative strategy to identify mutations -- Determination of the function of a mutant in a gene -- Confirmation of a mutation by multiple molecular approaches -- Confirmation of a mutation by microRNA -- Confirmation of function of a gene by translational approaches -- Confirmation of single nucleotide mutations -- Initial identification and confirmation of a QTL gene -- Gene discovery of crop diseases in the post genome era -- Impact of whole genome genetic element analysis on gene discovery of disease models -- Impact of whole genome protein analysis on gene discovery of disease models.

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